Azithromycin in posttransplant bronchiolitis obliterans syndrome.

نویسندگان

  • Robin Vos
  • Bart M Vanaudenaerde
  • Stijn E Verleden
  • Dirk E Van Raemdonck
  • Lieven J Dupont
  • Geert M Verleden
چکیده

Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Verleden receives an annual research grant from GlaxoSmithKline (GSK) Belgium, and is holder of the GlaxoSmithKline Chair in Respiratory Pharmacology at the Katholieke Universiteit Leuven, Leuven, Belgium. The remaining authors have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml ).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Azithromycin and bronchiolitis obliterans syndrome after lung transplantation: is prevention better than cure?

A lthough lung transplantation is now accepted as an established therapy for selected patients with end-stage lung disease, long-term survival after lung transplantation remains limited by the development of bronchiolitis obliterans syndrome (BOS) in .50% of recipients [1]. BOS is the clinical manifestation of an inflammatory bronchiolitis associated with fibrotic remodelling of the small and m...

متن کامل

A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy.

Bronchiolitis obliterans syndrome (BOS) is the most important cause of late mortality following lung transplantation, resulting in major morbidity and a huge burden on healthcare resources. Treatment options are limited, resulting in a mere stabilisation of the lung function decline. Recent introduction of the macrolide antibiotic azithromycin raised new hope after demonstrating lung function i...

متن کامل

Assessing the performance of the HAS-BLED score: is the C statistic sufficient?

We thank Dr Vos and colleagues for providing important additional studies that support the use of long-term azithromycin therapy to treat and, possibly, prevent posttransplant bronchiolitis obliterans syndrome (BOS). These studies should have been included in our review of chronic macrolide therapy in infl ammatory airways disease 1 but were not available at the time of submission. Their recent...

متن کامل

Effects of azithromycin therapy on bronchiolitis obliterans syndrome after lung transplant: a meta-analysis

Objectives: Azithromycin has been used for the treatment of patients with bronchiolitis obliterans (BOS) syndrome after lung transplant and it has been shown to be effective on improving lung function. The overall effect of azithromycin on the absolute values of FEV1 has not been compared between reported studies. We studied the effects of azithromycin on lung function in patients with post-lun...

متن کامل

Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal?

Chronic rejection (obliterative bronchiolitis) is the single most important cause of chronic allograft dysfunction and late mortality after lung transplantation. As this condition is difficult to prove using biopsy specimens, a clinical term, bronchiolitis obliterans syndrome (BOS) has been in use for >10 yrs to describe the progressive decrease of pulmonary function. However, before diagnosing...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Chest

دوره 139 5  شماره 

صفحات  -

تاریخ انتشار 2011